The Science
A naturally occurring molecule at the heart of satiety.
Oleoylethanolamide (OEA) is a lipid mediator produced in the small intestine after eating. It is one of the body's own signals in the regulation of appetite, energy balance and metabolic wellbeing.
From capsule to small intestine
How OLEACORE™ is designed to work
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Educational visualization: the ultramicronised OEA is suspended in a refined olive oil lipid carrier for delivery in the duodenum, where OEA is naturally produced after meals.
Satiety signalling
How OEA signals appetite regulation
Once released, OEA joins one of the body's own post-meal conversations — from the gut lining, to the PPAR-α receptor, to the brain via the vagal pathway.
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Educational visualization of published research on OEA signalling. OLEACORE® is a dietary supplement, not a treatment for any disease.
1. Produced after eating
Cells lining the small intestine synthesise OEA from dietary fats, particularly oleic acid — the main lipid in olive oil.
2. Activates PPAR-α
OEA binds the PPAR-α receptor, a key regulator of fatty-acid oxidation and metabolic gene expression in liver, muscle and fat tissue.
3. Signals satiety
It communicates with the brain via afferent nerves to support the natural feeling of fullness and healthy eating patterns.
Research foundation
Two decades of peer-reviewed OEA science.
OEA wasn't invented by a supplement brand. It was discovered in academic laboratories and characterised across more than twenty years of published research into satiety signalling, appetite regulation and gut–brain communication.
2001
First discovery
5
Landmark papers
10
Leading researchers
4
Countries
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2001Nature 414, 209–212In vivoPeer-reviewed
Rodríguez de Fonseca F, et al. An anorexic lipid mediator regulated by feeding.
First discovery that intestinal OEA is regulated by feeding.
DOI: 10.1038/35102582 -
2003Neuropsychopharmacology 28, 1311–1316In vivoPeer-reviewed
Gaetani S, Oveisi F, Piomelli D. Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide.
Showed OEA changes meal patterns by increasing satiety.
DOI: 10.1038/sj.npp.1300166 -
2003Nature 425, 90–93In vivoPeer-reviewed
Fu J, Gaetani S, et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α.
Identified PPAR-α as the key receptor mediating OEA's effects on appetite.
DOI: 10.1038/nature01921 -
2005Cellular and Molecular Life Sciences 62, 708–716ReviewPeer-reviewed
Lo Verme J, et al. Regulation of food intake by oleoylethanolamide.
Comprehensive review of OEA biology, metabolism and research potential.
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2014PNAS 111, 11527–11532In vivoPeer-reviewed
Provensi G, et al. Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake.
Demonstrated a central pathway linking gut-derived OEA to reduced food intake.
Prof. Daniele Piomelli
MD, PhD · University of California, Irvine · Italian Institute of Technology
Led the work establishing OEA as a satiety molecule acting through the PPAR-α receptor.
Fu J, Gaetani S, et al. (2003). Nature 425, 90–93.
Dr. Jin Fu
PhD · University of California, Irvine
First author of the landmark discovery paper linking OEA, feeding and body weight to PPAR-α.
Fu J, et al. (2003). Nature 425, 90–93.
Prof. Silvana Gaetani
MD, PhD · Sapienza University of Rome
Showed OEA delays meal initiation and prolongs satiety without causing illness or malaise.
Gaetani S, Oveisi F, Piomelli D. (2003). Neuropsychopharmacology 28, 1311–1316.
Dr. Jesse Lo Verme
PhD · University of California, Irvine
Authored the comprehensive review of OEA pharmacology, metabolism and appetite regulation.
Lo Verme J, et al. (2005). Cell Mol Life Sci 62, 708–716.
Prof. Fernando Rodríguez de Fonseca
MD, PhD · University of Córdoba · Hospital Carlos Haya, Spain
First identified OEA as an endogenous lipid whose intestinal levels rise after feeding.
Rodríguez de Fonseca F, et al. (2001). Nature 414, 209–212.
Prof. Maria Beatrice Passani
PhD · University of Florence
Demonstrated that OEA recruits the brain histaminergic system to inhibit food intake.
Provensi G, et al. (2014). PNAS 111, 11527–11532.
Dr. Gustavo Provensi
PhD · University of Florence
First author describing a central nervous system mechanism for OEA-induced satiety.
Provensi G, et al. (2014). PNAS 111, 11527–11532.
Prof. Patrizio Blandina
MD · University of Florence
Co-author on the histaminergic satiety pathway work, expanding gut–brain understanding.
Provensi G, et al. (2014). PNAS 111, 11527–11532.
Prof. Wolfgang Langhans
PhD · ETH Zurich
Clarified how peripheral OEA signalling contributes to meal termination and appetite control.
Karimian Azari E, et al. (2014). Langhans laboratory.
Dr. Myrtha Arnold
PhD · ETH Zurich
Published extensively on nutrient sensing and OEA-mediated control of feeding behaviour.
Gut–brain communication research programme, ETH Zurich.
Citations are provided for educational reference. These researchers and institutions are not affiliated with, and do not endorse, OLEACORE®. Much of the published work described above was conducted in animal models; OLEACORE® is a dietary supplement and is not intended to diagnose, treat, cure or prevent any disease.
Why ultramicronised
Formulated for advanced absorption.
OLEACORE™ uses an ultramicronised form of OEA suspended in a refined olive-oil lipid matrix. Smaller particle size and a natural lipid carrier are designed to support consistent, comfortable daily use.
Daily serving
300 mg
Per bottle
120 softgels
Ingredient philosophy
Everything essential. Nothing extra.
Ultramicronised OEA
The core active — 150 mg per softgel.
Refined olive oil
Natural lipid carrier for smooth, consistent delivery.
Sunflower lecithin
Supports emulsification and absorption.
Mixed tocopherols
Naturally derived vitamin E for oxidative stability.
Softgel capsule
Gelatin, purified water, calcium carbonate.
*These statements have not been evaluated by any regulatory authority. This product is not intended to diagnose, treat, cure or prevent any disease. Formulated to support healthy appetite, satiety and metabolic wellness as part of a balanced diet and lifestyle.